Hepatoprotective role of fruit extract of Terminalia arjuna in acetaminophen intoxicated mice
Abstract
Background: Liver injury and dysfunction is one of the major health concerns throughout the world. Several herbal formulations are reported to exert beneficial effects on the biochemistry of the liver.
Methods: Therefore, the current project is conducted to evaluate the hepatocurative and hepatoprotective potential of Terminalia arjuna by using albino mice.
Results: The fruit extract (400 mg/Kg) of the plant showed hepatoprotective effects upon pre-treatment for 5, 10 and 15 days and later challenged with acetaminophen (400 mg/Kg) for 3 days. The results showed substantial protective properties as there was comparatively less damage to the liver. Furthermore, the fruit extract of T. arjuna also exhibited hepatocurative effects when animals were given acetaminophen (400 mg/Kg) for 3 days to damage the liver followed by the treatment with the plant extract (400 mg/Kg) for 5, 10 and 15 days. The results also indicated hepatocurative activities, as the elevated serum levels of hepatic enzymes were inclining to normal ranges in a time-dependent manner.
Conclusion: In conclusion, the fruit extract of T. arjuna possesses hepatoprotective plus hepatocurative activities.
Keywords: Acetaminophen; Hepatocurative; Hepatoprotective; Serum Enzymes; Terminalia arjuna
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DOI: http://dx.doi.org/10.62940/als.v8i1.919
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