Probiotics and Human Health: Exploring the Interconnection with Host Microbiota
Abstract
The article examines the impact of probiotics on human health, with a particular emphasis on their interaction with the host's microbiota. Methods. The review begins with an extensive search of literature in databases such as PubMed, Scopus, and Google Scholar to gather studies on the effects of probiotics on the composition of the microbiome, immune response, and metabolic functions. The authors emphasize that the human microbiota, which consists of various microorganisms, plays a crucial role in maintaining homeostasis, supporting the immune system, and regulating metabolic health. Studies show that probiotics, particularly Lactobacillus and Bifidobacterium strains, contribute to gut health by promoting beneficial bacteria, regulating the immune response, and inhibiting pathogen growth. According to research, probiotics can be an effective adjunct treatment for conditions associated with microbiota imbalance. They may offer benefits for neurological, metabolic, and immune health.
Keywords: Human Health; Probiotics; Microbiota; Gut Health; Immune System; Metabolic Health
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Cryan JF, O’Riordan KJ, Cowan CS, Sandhu KV, Bastiaanssen TFS, Boehme M, et al. The microbiota-gut-brain axis. Physiological Reviews, (2019); 99(4): 1877–2013.
Fan Y, Pedersen O. Gut microbiota in human metabolic health and disease. Nature Reviews Microbiology, (2021); 19(1): 55–71.
Cruz MC, Azinheiro S, Pereira SG. Modulation of gut microbiota by diet and probiotics: potential approaches to prevent gestational diabetes mellitus. Gut Microbiome, (2023); 4: 1-18.
Chu C, Murdock MH, Jing D, Won TH, Chung H, Kressel AM, et al. The microbiota regulate neuronal function and fear extinction learning. Nature, (2019); 574(7779): 543–548.
Depommier C, Vitale RM, Iannotti FA, Silvestri C, Flamand N, Druart C, et al. Beneficial effects of Akkermansia muciniphila are not associated with major changes in the circulating endocannabinoidome but linked to higher mono-palmitoyl-glycerol levels as new PPARα agonists. Cells, (2021); 10(1): 1-22.
Blacher E, Bashiardes S, Shapiro H, Rothschild D, Mor U, Dori-Bachash M, et al. Potential roles of gut microbiome and metabolites in modulating ALS in mice. Nature, (2019); 572(7770): 474–480.
George Kerry R, Patra JK, Gouda S, Park Y, Shin H-S, Das G. Benefaction of probiotics for human health: A review. Journal of Food and Drug Analysis, (2018); 26(3): 927–939.
Burberry A, Wells MF, Limone F, Couto A, Smith KS, Keaney J, et al. C9orf72 suppresses systemic and neural inflammation induced by gut bacteria. Nature, (2020); 582(7810): 89–94.
Leonard JM, Toro DD. Defining the Microbiome Components (Bacteria, Viruses, Fungi) and Microbiome Geodiversity. Surgical Infections, (2023); 24(3): 208–212.
Boahen A, Than LT, Loke Y-L, Chew SY. The antibiofilm role of biotics family in vaginal fungal infections. Frontiers in Microbiology, (2022); 13: 1-21.
Wu Y, Hu S, Wu C, Gu F, Yang Y. Probiotics: Potential novel therapeutics against fungal infections. Frontiers in Cellular and Infection Microbiology, (2022); 11: 1-6.
Das S, Konwar BK. Prophylactic application of vaginal lactic acid bacteria against urogenital pathogens and its prospective use in sanitary suppositories. International Microbiology, (2024); 27(1): 179–202.
France M, Alizadeh M, Brown S, Ma B, Ravel J. Towards a deeper understanding of the vaginal microbiota. Nature Microbiology, (2022); 7(3): 367–378.
Naumova N, Alikina T, Tupikin A, Kalmykova A, Soldatova G, Vlassov V, et al. Human gut microbiome response to short-term Bifidobacterium-based probiotic treatment. Indian Journal of Microbiology, (2020); 60(4): 451–457.
Turroni F, Duranti S, Milani C, Lugli GA, van Sinderen D, Ventura M. Bifidobacterium bifidum: A key member of the early human gut microbiota. Microorganisms, (2019); 7(11): 1-35.
Wong CB, Odamaki T, Xiao J. Beneficial effects of Bifidobacterium longum subsp. longum BB536 on human health: modulation of gut microbiome as the principal action. Journal of Functional Foods, (2019); 54: 506–519.
Yao S, Zhao Z, Wang W, Liu X. Bifidobacterium Longum: Protection against inflammatory bowel disease. Journal of Immunology Research, (2021); 2021(1): 1-11.
Kyser AJ, Masigol M, Mahmoud MY, Ryan M, Lewis WG, Lewis AL, et al. Fabrication and characterization of bioprints with Lactobacillus crispatus for vaginal application. Journal of Controlled Release: Official Journal of the Controlled Release Society, (2023); 357: 545–560.
Marinacci B, Pellegrini B, Roos S. A mini-review: Valuable allies for human health: probiotic strains of Limosilactobacillus reuteri. Italian Journal of Anatomy and Embryology, (2023); 127(2): 57-60.
Ma Y, Li Y, Liu Y, Cao L, Han X, Gao S, et al. Vaginal Microbiome Dysbiosis is Associated with the Different Cervical Disease Status. Journal of Microbiology, (2023); 61(4): 423–432.
Ait Chait Y, Mottawea W, Tompkins TA, Hammami R. Evidence of the dysbiotic effect of psychotropics on gut microbiota and capacity of probiotics to alleviate related dysbiosis in a model of the human colon. International Journal of Molecular Sciences, (2023); 24(8): 1-15.
Aldegheri L, Kharrat F, Conti A, Monica F, Busa F, Campisciano G, et al. Impact of human milk oligosaccharides and probiotics on gut microbiome and mood in autism: a case report. Microorganisms, (2024); 12(8): 1-10.
At R, Mitra A, Banerjee A, Ilanchoorian D, Radhakrishnan AK. Current understanding of gut microbiome alterations and therapeutic approaches for improving human health. International Journal of Experimental Research and Review, (2023); 36: 253–264.
Horvath A, Zukauskaite K, Hazia O, Balazs I, Stadlbauer V. Human gut microbiome: Therapeutic opportunities for metabolic syndrome – Hype or hope? Endocrinology, Diabetes & Metabolism, (2024); 7(1): 1-32.
Magill RG, MacDonald SM. Male infertility and the human microbiome. Frontiers in Reproductive Health, (2023); 5: 1-7.
Kim Y-T, Mills DA. Exploring the gut microbiome: Probiotics, prebiotics, synbiotics, and postbiotics as key players in human health and disease improvement. Food Science and Biotechnology, (2024); 33(9): 2065–2080.
Bock PM, Martins AF, Schaan BD. Understanding how pre- and probiotics affect the gut microbiome and metabolic health. American Journal of Physiology-Endocrinology and Metabolism, (2024); 327(1): 89–102.
Maftei N-M, Raileanu CR, Balta AA, Ambrose L, Boev M, Marin DB, et al. The Potential Impact of Probiotics on Human Health: An Update on Their Health-Promoting Properties. Microorganisms, (2024); 12(2): 1-29.
Chee WJY, Chew SY, Than LT. Vaginal microbiota and the potential of Lactobacillus derivatives in maintaining vaginal health. Microbial Cell Factories, (2020); 19(1): 1-24.
Bradfield Strydom M, Khan S, Walpola RL, Ware RS, Tiralongo E. Interplay of the microbiome and antifungal therapy in recurrent vulvovaginal candidiasis (RVVC): a narrative review. Journal of Medical Microbiology, (2023); 72(5): 1-7.
Mousa WK, Mousa S, Ghemrawi R, Obaid D, Sarfraz M, Chehadeh F, et al. Probiotics modulate host immune response and interact with the gut microbiota: shaping their composition and mediating antibiotic resistance. International Journal of Molecular Sciences, (2023); 24(18): 1-17.
Shoemaker WR. A macroecological perspective on genetic diversity in the human gut microbiome. PLOS ONE, (2023); 18(7): 1-28.
Singh J, Vanlallawmzuali, Singh A, Biswal S, Zomuansangi R, Lalbiaktluangi C, et al. Microbiota-brain axis: Exploring the role of gut microbiota in psychiatric disorders - A comprehensive review. Asian Journal of Psychiatry, (2024); 97: 1-15.
Zhou X, Zhang X, Yu J. Gut mycobiome in metabolic diseases: Mechanisms and clinical implication. Biomedical Journal, (2024); 47(3): 1-12.
Palmnäs-Bédard MS, Costabile G, Vetrani C, Åberg S, Hjalmarsson Y, Dicksved J, et al. The human gut microbiota and glucose metabolism: A scoping review of key bacteria and the potential role of SCFAs. The American Journal of Clinical Nutrition, (2022); 116(4): 862–874.
Cani PD. Targeting gut microbiota with a complex mix of dietary fibers improves metabolic diseases. Kidney International, (2019); 95(1): 14–16.
He J, Zhang P, Shen L, Niu L, Tan Y, Chen L, et al. Short-Chain Fatty Acids and Their Association with Signalling Pathways in Inflammation, Glucose and Lipid Metabolism. International Journal of Molecular Sciences, (2020); 21(17): 1-16.
Cani PD, Moens de Hase E, Van Hul M. Gut microbiota and host metabolism: from proof of concept to therapeutic intervention. Microorganisms, (2021); 9(6): 1-16.
Shinoda A, Lkhagvajav T, Mishira R, Therdtatha P, Jamiyan D, Purevdorj C, et al. Gut microbiome signatures associated with type 2 diabetes in obesity in Mongolia. Frontiers in Microbiology, (2024); 15: 1-13.
Wachsmuth H, Lane A, Meyer R, Weninger S, Duca FA. Colonic butyrate lowers hepatic glucose production via FFAR2-dependent GLP-1 receptor neuronal signaling. Physiology, (2023); 38(S1): 1-21.
Zhang E, Ceballos HM, Huang W. 2042-LB: The gut–fat cross talk in metabolic regulation through microbiome. Diabetes, (2024); 73(Supplement_1): 1-17.
Gopalakrishnan V, Helmink BA, Spencer CN, Reuben A, Wargo JA. The Influence of the Gut Microbiome on Cancer, Immunity, and Cancer Immunotherapy. Cancer Cell, (2018); 33(4): 570–580.
Ispas S, Tuta LA, Botnarciuc M, Ispas V, Staicovici S, Ali S, et al. Metabolic Disorders, the Microbiome as an Endocrine Organ, and Their Relations with Obesity: A Literature Review. Journal of Personalized Medicine, (2023); 13(11): 1-23.
Pezeshki A. The role of gut microbiota on regulation of growth and metabolism by branched-chain amino acids. Journal of Animal Science, (2024); 102(Supplement_2): 1-2.
Martinez TM, Wachsmuth HR, Meyer RK, Weninger SN, Lane AI, Kangath A, et al. Differential effects of plant-based flours on metabolic homeostasis and the gut microbiota in high-fat fed rats. Nutrition & Metabolism, (2023); 20(1): 1-20.
Ragavan ML, Srinivasan H. Therapeutic potential of dietary phytochemicals from Drynaria quercifolia to modulate gut microbiome: An in silico approach. Journal of Biomolecular Structure and Dynamics, (2023); 42(21): 11508-11520.
Castonguay-Paradis S, Perron J, Flamand N, Lamarche B, Raymond F, Di Marzo V, et al. Dietary food patterns as determinants of the gut microbiome–endocannabinoidome axis in humans. Scientific Reports, (2023); 13(1): 1-10.
Kumar R, Kaur A, Rajput D. An Insight on Gut Flora, Colorectal Cancer Mechanism, and Treatment Strategies. Advanced Gut & Microbiome Research, (2023); 2023(1): 1-16.
Li M, Liu S, Wang M, Hu H, Yin J, Liu C, et al. Gut Microbiota Dysbiosis Associated with Bile Acid Metabolism in Neonatal Cholestasis Disease. Scientific Reports, (2020); 10(1): 1-10.
Zhang J, Zhang X, Liu H, Wang P, Li L, Bionaz M, et al. Altered bile acid and correlations with gut microbiome in transition dairy cows with different glucose and lipid metabolism status. Journal of Dairy Science, (2024); 107(11): 9915-9933.
Somm E, Jornayvaz FR. Fibroblast Growth Factor 15/19: From Basic Functions to Therapeutic Perspectives. Endocrine Reviews, (2018); 39(6): 960–989.
Li J, Zhang Z, Xu Y, Li W, Jiang S, Zhang J, et al. Limosilactobacillus fermentum HNU312 alleviates lipid accumulation and inflammation induced by a high-fat diet: Improves lipid metabolism pathways and increases short-chain fatty acids in the gut microbiome. Food & Function, (2024); 15(17): 8878–8892.
Hengist A, Davies RG, Walhin JP, Buniam J, Merrell LH, Rogers L, et al. Ketogenic diet but not free-sugar restriction alters glucose tolerance, lipid metabolism, peripheral tissue phenotype, and gut microbiome: RCT. Cell Reports Medicine, (2024); 5(8): 1-28.
Zhang F, Lo EKK, Chen J, Wang K, Felicianna, Ismaiah MJ, et al. Probiotic mixture ameliorates a diet-induced MASLD/MASH murine model through the regulation of hepatic lipid metabolism and the gut microbiome. Journal of Agricultural and Food Chemistry, (2024); 72(15): 8536–8549.
Cortés-Martín A, Iglesias-Aguirre CE, Marín A, Romo-Vaquero M, Vallejo F, Espín JC, et al. Urolithin A production drives the effects of pomegranate on the gut microbial metabolism of bile acids and cholesterol in mild dyslipidaemic overweight and obese individuals. Food & Function, (2024); 15(5): 2422–2432.
Chen X, Hou Y, Liao A, Pan L, Yang S, Liu Y, et al. Integrated analysis of gut microbiome and adipose transcriptome reveals beneficial effects of resistant dextrin from wheat starch on insulin resistance in Kunming mice. Biomolecules, (2024); 14(2): 1-17.
Guo Q, Li Y, Dai X, Wang B, Zhang J, Cao H. Polysaccharides: The Potential Prebiotics for Metabolic Associated Fatty Liver Disease (MAFLD). Nutrients, (2023); 15(17): 1-20.
Ma S, Takasugi S, Sugawara M, Saito K, Jia H, Kato H. Effects of Heat-Moisture-Treated High-Amylose Rice Flour on Body Weight, Lipid Metabolism, and Gut Microbiome Composition in Obese Rats. Metabolites, (2023); 13(7): Article 7.
Kolli U, Jalodia R, Moidunny S, Singh PK, Ban Y, Tao J, et al. Multi-omics analysis revealing the interplay between gut microbiome and the host following opioid use. Gut Microbes, (2023); 15(2): 1-20.
Sun W, Ding Y, Liu Z, Hou S, Sun D, Ma R, et al. Investigating the impact of HTNV infection on the gut microbiota of wild-type and NLRX1 knockout mice. Advanced Gut & Microbiome Research, (2024); 2024(1): 1-16.
Endres K, Friedland K. Talk to me – interplay between mitochondria and microbiota in aging. International Journal of Molecular Sciences, (2023); 24(13): 1-24.
Vilela C, Araújo B, Soares-Guedes C, Caridade-Silva R, Martins-Macedo J, Teixeira C, et al. From the gut to the brain: is microbiota a new paradigm in Parkinson’s disease treatment? Cells, (2024); 13(9): 1-25.
Ebedes D, Borlongan CV. Going straight for the gut: gut-brain axis pathology and treatment of Parkinson’s disease. Neural Regeneration Research, (2024); 19(10): 1-2.
Leszek J. The Gut Microbiome Alterations and Inflammation-driven Pathogenesis of Alzheimer’s Disease. In M. Baudry (Ed.), IABS Forum 2023 (p. 32). International Association of Biomedical Sciences (IABS).
Marizzoni M, Mirabelli P, Mombelli E, Coppola L, Festari C, Lopizzo N, et al. A peripheral signature of Alzheimer’s disease featuring microbiota-gut-brain axis markers. Alzheimer’s Research & Therapy, (2023); 15(1): 1-12.
Li Y, Deng Q, Liu Z. The relationship between gut microbiota and insomnia: A bi-directional two-sample Mendelian randomization research. Frontiers in Cellular and Infection Microbiology, (2023); 13: 1-10.
Cheng J, Hu H, Ju Y, Liu J, Wang M, Liu B, et al. Gut microbiota-derived short-chain fatty acids and depression: deep insight into biological mechanisms and potential applications. General Psychiatry, (2024); 37(1): 1-16.
Zhao H, Chen X, Zhang L, Tang C, Meng F, Zhou L, et al. Ingestion of Lacticaseibacillus rhamnosus Fmb14 prevents depression-like behavior and brain neural activity via the microbiota–gut–brain axis in colitis mice. Food & Function, (2023); 14(4): 1909–1928.
Bertossi F. A possible role of Akkermansia muciniphila in the treatment of olanzapine-induced weight gain. Cureus, (2024); 16(3): 1-9.
Tandon D, Haque MM, Gote M, Jain M, Bhaduri A, Dubey AK, et al. A prospective randomized, double-blind, placebo-controlled, dose-response relationship study to investigate efficacy of fructo-oligosaccharides (FOS) on human gut microflora. Scientific Reports, (2019); 9(1): 1-15.
Gulrandhe P, Acharya S, Shukla S, Patel M, Gulrandhe P, Acharya S, et al. Neuropsychiatric and Neurological Diseases in Relation to the Microbiota-Gut-Brain Axis: From Research to Clinical Care. Cureus, (2023); 15: 1-8.
Wang Q, Yang Q, Liu X. The microbiota–gut–brain axis and neurodevelopmental disorders. Protein & Cell, (2023); 14(10): 762–775.
Vasilev VL, Gapsalamov AR, Akhmetshin EM, Bochkareva TN, Yumashev AV, & Anisimova TI. Digitalization peculiarities of organizations: A case study. Entrepreneurship and Sustainability Issues, (2020); 7(4): 3173-3190.
Ryzhova K, Yumashev AV, Klimova M, Osin R, Gracheva E, Dymchishina A. Artificial intelligence in the diagnosis of diseases of various origins. Journal of Complementary Medicine Research, (2023); 14(2): 199-202.
DOI: http://dx.doi.org/10.62940/als.v12i4.3673
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