Correlation between Neutrophil Gelatinase Associated with Lipocaline and Megalin in Type 2 Diabetic patients
Abstract
Background: Type 2 Diabetes Mellitus (T2DM) is a metabolic disorder defined via elevated blood glucose caused by insufficiency of insulin-sensitive tissues to respond to insulin or defective insulin production by pancreatic β-cells due to environmental and genetic factors. Megalin is a glycoprotein that is mostly found in the proximal tubular cells, major role is to reabsorb albumin and other proteins that the glomerulus has filtered in the proximal tubules.
Methods: The purpose of research measure the concentration of megalin and Neutrophil Gelatinase Associated Lipocalin (NGAL) in type 2 patients, in the period from December 2022 to March 2023 at the Baghdad Teaching Hospital120 participants aged(30-60) years, the measured concentration of Megalin, NGAL, and fasting blood glucose in serum and whole blood estimated for glycated hemoglobin (HbA1C).
Results: The result indicates blood glucose concentration in patients with T2DM (344.975±63.68mg/dl) was significantly higher than control(106.62±12.59mg/dl), HbA1C (13.40±10.35%) in T2DM patients was significantly higher than control (4.310±0.336%), Megalin levels revealed for T2DM patients (220.70±42.47pg/ml) significantly higher than control (120.42±29.33pg/ml), NGAL(447.68±62.76pg/ml) in T2DM patients higher than control(264.93±51.79 pg/ml).
Conclusion: According to the results NGAL and Megalin levels were significantly higher in T2DM patients as compared to controls play a role in diabetes pathogenesis and as biomarkers for the early identification of diabetic nephropathy.
Keywords: Type 2 diabetes; Megalin; Neutrophil Gelatinase; Associated Lipocalin
Editorial Expression of Concern
20 June 2025: Following publication of this paper, the internal audit (consequent to concerns on quality raised by Web of Science) notified Advancements in Life Sciences about insufficient peer review. By this Editorial Expression of Concern, we alert the scientific community of this incidence as we asses if the reported scientific findings are reliable.
Editorial Note
26 June 2025: Post-publication review of this paper by a member of the editorial board has highlighted significant limitations related to the rationale of the methodology, p-value formatting, and language usage. The authors have been requested to make post-publication corrections. Nonetheless, readers are advised to interpret and use the findings with due consideration of the above comments. The Editorial Expression of Concern will be revoked upon completion of the necessary corrections by the authors.
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DOI: http://dx.doi.org/10.62940/als.v10i0.1990
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