Rh alleles and phenotypes among Saudi women in Hail Region, Saudi Arabia

Jerold C. Alcantara, Tessie Y. Alcantara, Khalid Al Shaghdali, Fawaz D Alshammari, Fahad Ghali M Al Shammari

Abstract


Background: The Rh system is considered as the most complex among the human blood group systems, with 61 antigens identified to date. This study aimed to provide preliminary data on the distribution of Rh alleles and phenotypes among Saudi women and compare them with other ethnic groups.

Methods: This retrospective cross-sectional study was conducted among Saudi women who visited the Maternity and Children Hospital of Hail from November 2019 to March 2020. A fully automated blood bank analyzer was used in determining the Rh subgroups (D, C, c, E, e) and phenotypes. Inferential statistics and chi-square tests were used appropriately for comparisons.

Results: The study included a total of 500 Saudi female patients. The most prevalent antigen found was the “e” antigen, while phenotype CcDee has shown to have the highest frequency. A significant difference exists in comparison with the other studies from various ethnic groups.

Conclusions: The prevalence and distributions of Rh alleles and phenotypes among Saudi women were revealed in this study. The findings showed that Rh alleles and phenotypes are diverse across various races and regions globally.

Keywords: Rh allele; Rh phenotype; Rh system; Saudi Arabia


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References


Denomme GA WCTRSiMF, BJ. Grossman, CD Hillyer & CM Westhoff (Edition). Technical Manual 18th edition. Maryland: American Association of Blood Banks. (2014); pp: 317-321..

Johnson ST WM. The Rh Blood Groups System’ in DM. Harmening (Eds). Modern Blood Banking and Transfusion Practices 6th ed. (2012); pp: 160-161.

Rh DG. RHAG blood group systems. Human blood groups 3rd Ed Oxford (UK): Wiley-Blackwell, (2013); 185.

Frohn C, Dumbgen L, Brand JM, Gorg S, Luhm J, et al. Probability of anti-D development in D- patients receiving D+ RBCs. Transfusion, (2003); 43(7): 893-898.

Klein, H. G. "Immunology of red cells In: Klein HG, Anstee DJ., editors. Mollison's blood transfusion in clinical medicine. Oxford." (2005): 48-113.

Achargui S, Zidouh A, Abirou S, Merhfour FZ, Monsif S, et al. [Identification of alloantibodies and their associations: Balance sheet of 3 years at the Regional Center of Blood Transfusion in Rabat/Morocco and difficult in transfusion management]. Transfusion Clinique et Biologique, (2017); 24(4): 422-430.

Reid, Marion E., Christine Lomas-Francis, and Martin L. Olsson. The blood group antigen factsbook. Academic press, 2012.

Daniels G. Human Blood Groups (2nd edn). Transfusion Medicine, (2004); 14(4): 326-326.

Elsayid M, Al Qahtani FS, Al Qarni AM, Almajed F, Al Saqri F, et al. Determination of the frequency of the most immunogenic Rhesus antigens among Saudi donors in King Abdulaziz Medical City – Riyadh. Journal of Natural Science, Biology and Medicine, (2017); 8(1): 56-59.

Levine P, Stetson RE. An unusual case of intra-group agglutination. Journal of the American Medical Association, (1939); 113(2): 126-127.

Scott ML. The complexities of the Rh system. Vox Sanguinis, (2004); 87 Suppl158-62.

Mazières S, Temory SA, Vasseur H, Gallian P, Di Cristofaro J, et al. Blood group typing in five Afghan populations in the North Hindu‐Kush region: implications for blood transfusion practice. Transfusion Medicine, (2013); 23(3): 167-174.

Talib ZM, Al-Nuaim LA, El-Hazmi MA, Warsy AS. Blood groups in Saudi obstetrics patients. Saudi Medical Journal, (1998); 19(3): 260-264.

Francoise NS DT, Bernanrd CC, Rene E. Erythrocyte alloimmunization, Rhesus and Kell phenotype for women of childbearing

age in Yaounde. Journal of Medical Research (2018); 4(1): 20-23.

Mahmood R, Alam M, Altaf C, Abbasi A, Malik H. Phenotypic profile of Rh blood group systems among females of child-bearing age in Pakistan. Hematology & Transfusion International Journal, (2018); 6(1): 00148.

Erhabor O, Adamu KS, Yakubu A, Shehu C, Hassan M. Singh S.. Rh (D) Phenotype among Pregnant Women in Sokoto, North Western Nigeria. Implications on Haemolytic Disease of the New-Born and Haemolytic Transfusion Reaction. Health Science Research, (2014); 1(2): 19-24.

Osaro E, Ladan MA, Zama I, Ahmed Y, Mairo H. Distribution of Kell phenotype among pregnant women in Sokoto, North Western Nigeria. The Pan African Medical Journal, (2015); 21,(1).

Jeremiah ZA, Biribo AA, Adias TC, Uko EK. Uncommon Rh phenotypes in a cross section of Nigerian antenatal women: implications for molecular genotyping of blood groups. Journal of Blood Disorders and Transfusion, (2012); 10: 001.

El-Wahhab Skaik YA. The Rh allele frequencies in Gaza city in Palestine. Asian Journal of Transfusion Science, (2011); 5(2): 150-152.

Mustafa MHI, Elmisbah TE, Salim A, Ahmed MAM, Babiker S, et al. RHD and RHCE frequencies and gene complexes among major tribes of Turabah Province, Saudia Arabia. International Journal of Multidisciplinary

and Current Research, (2014); (2), 2573-578.

Wagner FF, Kasulke D, Kerowgan M, Flegel WA. Frequencies of the blood groups ABO, Rhesus, D category VI, Kell, and of clinically relevant high-frequency antigens in south-western Germany. Infusion Therapy and Transfusion Medicine, (1995); 22(5): 285-290.

Dinardo CL. Red blood cell alloantibodies and autoantibodies: different presentation, same physiopathology. Hematology, Transfusion and Cell Therapy, (2018); 40(2): 99-100.

Klapper E, Zhang Y, Figueroa P, Ness P, Stubbs J, et al. Toward extended phenotype matching: a new operational paradigm for the transfusion service. Transfusion, (2010); 50(3): 536-546.

Sood R, Makroo RN, Riana V, Rosamma NL. Detection of alloimmunization to ensure safer transfusion practice. Asian Journal of Transfusion Science, (2013); 7(2): 135-139.

Singer ST, Wu V, Mignacca R, Kuypers FA, Morel P, et al. Alloimmunization and erythrocyte autoimmunization in transfusion-dependent thalassemia patients of predominantly asian descent. Blood, (2000); 96(10): 3369-3373.

Da Rocha Lopes, L. "Genetic determinants and genotype-phenotype associations in hypertrophic cardiomyopathy-Contribution of a high-throughput sequencing approach." PhD dissertation., UCL (University College London), 2015.

Peyrard T, Rouger P, Transfusion and obstetrical safety of people with a rare blood group; Hématologie, (2010); 16(2): 143-55.

El Housse H, El Wafi M, Ouabdelmoumene Z, Zarati F, Alid R, et al. Comprehensive phenotypic and molecular investigation of RhD and RhCE variants in Moroccan blood donors. Blood Transfusion, (2019); 17(2): 151-156.




DOI: http://dx.doi.org/10.62940/als.v8i2.1001

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